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KMID : 0379520020180030241
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한국독성학회지
2002 Volume.18 No. 3 p.241 ~ p.248
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A 4-week Repeated Oral Dose Toxicity Study of CJ-10882 in Dogs
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Cha Shin-Woo
Kim Jong-Choon
Kim Dai-Hyun
Chung Moon-Koo
Han Jeong-Hee
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Abstract
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The present study was conducted to investigate the potential subacute toxicity of CJ-10882 by a 4-week repeated oral dose in dogs. The test article was administered once dally by gavage to dogs at dose levels of 0, 2, 10, and 50 mg/kg/day for 4 weeks. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross finding, organ weight, and histopathology were evaluated. Several clinical sign were observed in treated dogs at 50 mg/kg, including salivation and vomiting. Increase in the serum level of ALT and albumin observed in the female 50 mg/kg group was considered as a toxic effect related to the test article since the histopathological change in Liver was accompanied. There were no treatment-related effects on mortality, food and water consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings and organ weights in any treatment group. Based on these results, target organ was not observed and the no-observed-adverse-effect level (NOAEL) was 10 mg/kg/day and the absolute toxic dose was 50 mg/kg for both male and female dogs.
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KEYWORD
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CJ-10882, Subacute toxicity study, Dogs
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